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. 2019 Sep 25;6:148. doi: 10.3389/fnut.2019.00148

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Copyright © 2019 Farcas, Gavrea, Gulei, Ionescu, Irimie, Catana and Berindan-Neagoe.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparative representation of MRPS5 signaling in liver cancer stem cells and HCC cells. In LCSCs, SIRT1 deacetylates MRPS5, which promotes its mitochondrial localization. Mitochondrial MRPS5 increases oxidative phosphorylation and consequently ROS. However, SIRT1 also promotes UPRmt activity, which decreases ROS levels. Conversely, in HCC cells, MRPS5 is localized in the nucleus where its activity promotes increased cellular glycolysis. All the figures in this article were made using images from http://smart.servier.com.