Table 1.

Molecules involved in the biology of LCSCs and their interaction with SIRT1.

	Role in HCC	Interaction with SIRT1	Comments	References
MRPS5	↑LCSCs mitochondrial function and NAD levels	SIRT1 deacetylates MRPS5 and promotes its nuclear localization	Metformin ↓MRPS5	(101)
SOX2	↑LCSCs self-renewal ↑Tumorigenicity	SIRT1 promotes SOX2 expression	SIRT1 inhibitors TV6 and EX-527 ↓SOX2	(88)
MEK1	↑Proliferation and oncogenesis of LCSC	MEK1 ↑ SIRT1 expression in LCSC	↑MEK-SIRT1 expression correlated with HCC metastasis	(46)
LSD1	↑LCSCs self-renewal and tumorigenesis	SIRT1 deacetylates LSD1 and prevents its degradation	↑SOX2 expression	(119)
CPEB1	↓Chemoresistance ↓Stemness ↑Apoptosis	↓SIRT1 expression	CPEB1 expression is ↓ in LCSCs and HCC	(124)