Table 2. Statistical parameter of factorial design for nano-polymeric micelle delivery system .

Parameters	Solubility (µg/mL)		Particle size (nm)		PDI		Entrapment efficiency (%)
	Coef.	P value	Coef.	P value	Coef.	P value	Coef.	P value
Intercept	19.76	-	278.25	-	0.52	-	69.01	-
A	1.09	0.0221	-56.13	<0.001	-0.24	<0.001	2.64	0.002
B	-12.79	<0.001	-35.83	<0.001	0.13	<0.001	-6.99	<0.001
AB	-2.78	<0.001	25.38	<0.001	-3.4x10-3*	0.794	0.14	<0.001
Model		<0.001		<0.001		<0.001		<0.001
Curvature		0.520*		<0.001		<0.001		0.769*
R2	0.9907		0.9956		0.9791		0.9623
Adj. R2	0.9880		0.9942		0.9728		0.9509
Pred. R2	0.9792		0.9900		0.9530		0.9151
Adeq. Prec	38.77		61.07		29.23		20.58

A = _D-L-lactide to glycolide ratio; B = PEG 1000; PDI = polydispersity index.

Coef. = regression coefficient; R² = coefficient of determination, Adj. R² = Adjusted R²; Pred. R² = Predicted R²; Adeq. Prec. = adequate precision.

* Statistically not significant difference (P > 0.05).