Table 1.
The effect of the h-BN-OH nanoflakes on RBCs after different incubation times (1 hour, 4 hours, and 24 hours at 37 °C) at the given concentration. Haemolysis above 5% indicates weak haemolytic activity
| Concentration/Incubation condition | 10−7 g/ml | 10−8 g/ml | 10−9 g/ml | |||
|---|---|---|---|---|---|---|
| Haemolytic activity (%) | Dominate RBC shape | Haemolytic activity (%) | Dominate RBC shape | Haemolytic activity (%) | Dominate RBC shape | |
| 1 h, 37 °C | ||||||
| Control (PBS) | 1.44 ± 0.52 | D | 1.72 ± 0.36 | D | 1.49 ± 0.73 | D |
| h-BN-OH | 3.78 ± 0.86 | D | 2.73 ± 1.25 | D | 1.91 ± 1.24 | D |
| 4 h, 37 °C | ||||||
| Control (PBS) | 1.61 ± 0.68 | D | 1.97 ± 0.83 | D | 2.07 ± 0.49 | D |
| h-BN-OH | 4.18 ± 0.39 | D | 3.08 ± 0.64 | D | 2.19 ± 1.25 | D |
| 24 h, 37 °C | ||||||
| Control (PBS) | 3.81 ± 0.72 | D/DE | 3.32 ± 1.16 | D/DE | 3.25 ± 0.63 | D/DE |
| h-BN-OH | 8.16 ± 1.09 | D/DE | 6.85 ± 1.64 | D/DE | 4.22 ± 0.35 | D/DE |
The presented values are the mean ± SD of three independent experiments with RBCs from different donors; abbreviations: D – discocytes (as control cells), DE – discoechinocytes.