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Performance of male and female wild-type (WT) and 3xTg-AD mice given vehicle or DWG-1036 on the elevated plus maze. (A) Mean (±SEM) distance (in centimeters) traveled by the mice, a measure of locomotor behavior. (B) Mean (+SEM) frequency of visiting the open arms, a measure of reduced anxiety. (C) Mean (+SEM) frequency of freezing behavior, a measure of anxiety. *’s are used to present individual group differences determined by 95% confidence intervals.
