Fig. 3.

(A–D) Hematoxylin–eosin staining (x100). Mesenchymal stem cells treated with TGF-β1 (group T) display a cobblestone-like shape and a higher cell density. Cells in the L, T+L, and T/L groups display a slightly extending cytoplasm (arrow). Group T: 10 ng/mL TGF-β1; group L: 5 M lovastatin; group T+L: simultaneous treatment with 10 ng/mL TGF-β1 and 5 M lovastatin; and group T/L: sequential treatment with 10 ng/mL TGF-β1 for 72 hours then 5 M lovastatin for 11 days. TGF-β1, transforming growth factor-beta1.