Table 2.
The common genes between XSN target spectrum and PHHD-arrhythmia target spectrum.
| Gene_Symbol | TCM_Symptom | Target_Weight_Coefficient | UniProt_ID | ChEMBL_ID | Target_Name | Classification_1 | Classification_2 |
|---|---|---|---|---|---|---|---|
| CALM1 | Maijiedai, Xuanyun | 790.2976034 | P0DP23 | CHEMBL6093 | Calmodulin | Other | Unclassified protein |
| KCNH2 | Maijiedai, Xinji | 13942.14102 | Q12809 | CHEMBL240 | HERG | Ion channel | VGIC |
| TP53 | Yijing, Maijiedai, Xinji | 13900.81344 | P04637 | CHEMBL4096 | Cellular tumor antigen p53 | Transcription factor | Other |
| ABCC8 | Maijiedai | 13817.52659 | Q09428 | CHEMBL2071 | Sulfonylurea receptor 1 | Transporter | Other |
| KCNJ11 | Maijiedai | 13817.40799 | Q14654 | CHEMBL1886 | Potassium channel, inwardly rectifying, subfamily J, member 11 | Ion channel | VGIC |
| KCNJ5 | Maijiedai | 169.079052 | P48544 | CHEMBL3038488 | Kir3.1/Kir3.4 | Ion channel | VGIC |
| CACNA1B | Maijiedai | 593.6573686 | Q00975 | CHEMBL4478 | Voltage-gated N-type calcium channel alpha-1B subunit | Ion channel | VGIC |
| TARDBP | Kougan | 2584.201263 | Q13148 | CHEMBL2362981 | TAR DNA-binding protein 43 | Other | Unclassified protein |
| JAK2 | Xuanyun | 2032.705321 | O60674 | CHEMBL2971 | Tyrosine-protein kinase JAK2 | Kinase | Protein Kinase |
| TNNC1 | Maijiedai | 2017.925664 | P63316 | CHEMBL2095202 | Troponin, cardiac muscle | Other | Other |
| TNNI3 | Maijiedai | 2017.925664 | P19429 | CHEMBL2095202 | Troponin, cardiac muscle | Other | Other |
| TNNT2 | Maijiedai | 2017.925664 | P45379 | CHEMBL2095202 | Troponin, cardiac muscle | Other | Other |
| GMNN | Xiongmen | 95.88983101 | O75496 | CHEMBL1293278 | Geminin | Other | Unclassified protein |
| SMAD3 | Maijiedai | 95.88983101 | P84022 | CHEMBL1293258 | Mothers against decapentaplegic homolog 3 | Other | Unclassified protein |
| PPARG | Maijiedai, Xinji | 83.46168023 | P37231 | CHEMBL235 | Peroxisome proliferator-activated receptor gamma | Transcription factor | Nuclear receptor |
| GJA1 | Maijiedai | 83.29977996 | P17302 | Gap junction alpha-1 protein | Other | Unclassified protein | |
| PTPN11 | Maijiedai | 83.26574007 | Q06124 | CHEMBL3864 | Protein-tyrosine phosphatase 2C | Enzyme | Phosphatase |
| LMNA | Maijiedai | 83.14071435 | P02545 | CHEMBL1293235 | Prelamin-A/C | Other | Unclassified protein |
| TSHR | Maijiedai | 83.14071435 | P16473 | CHEMBL1963 | Thyroid-stimulating hormone receptor | GPCR | Family A GPCR |
| ATXN2 | Kougan | 12.74911666 | Q99700 | CHEMBL1795085 | Ataxin-2 | Other | Unclassified protein |
| SOD1 | Kougan | 1.975815734 | P00441 | CHEMBL2354 | Superoxide dismutase | Enzyme | Oxidoreductase |
| SDHA | Yijing, Maijiedai, Xinji, Xuanyun | 1.990418899 | P31040 | CHEMBL5758 | Succinate dehydrogenase (ubiquinone) flavoprotein subunit, mitochondrial | Enzyme | Oxidoreductase |
| PON1 | Kougan | 1.732079071 | P27169 | CHEMBL3167 | Serum paraoxonase/arylesterase 1 | Enzyme | Hydrolase |
| KYNU | Maijiedai | 1.649920118 | Q16719 | CHEMBL5100 | Kynureninase | Enzyme | Hydrolase |
| IFNG | Maijiedai | 1.695300734 | P01579 | CHEMBL3286073 | Interferon gamma | Other | Other |
| CHRM3 | Kougan | 0.769622544 | P20309 | CHEMBL245 | Muscarinic acetylcholine receptor M3 | GPCR | Family A GPCR |
| SCN5A | Maijiedai, Xinji | 76.0137842 | Q14524 | CHEMBL1980 | Sodium channel protein type V alpha subunit | Ion channel | VGIC |
| DAO | Kougan | 1.396943488 | P14920 | CHEMBL5485 | D-amino-acid oxidase | Enzyme | Oxidoreductase |
| CPT2 | Maijiedai, Xiongmen | 1.020829585 | P23786 | CHEMBL3238 | Carnitine palmitoyltransferase 2 | Enzyme | Transferase |
| CTNNB1 | Xuanyun | 1.020829585 | P35222 | CHEMBL5866 | Catenin beta-1 | Other | Unclassified protein |
| NAGS | Xiongmen | 1.020829585 | Q8N159 | N-acetylglutamate synthase, mitochondrial | Enzyme | Transferase | |
| TTR | Maijiedai | 1.001902474 | P02766 | CHEMBL3194 | Transthyretin | Other | Other |
| COL3A1 | Xuanyun | 0.45282272 | P02461 | CHEMBL2364188 | Collagen | Other | Other |
| SLC1A3 | Xuanyun | 0.520835938 | P43003 | CHEMBL3085 | Excitatory amino acid transporter 1 | Transporter | Electrochemical transporter |
| HNF4A | Maijiedai | 0.386540369 | P41235 | CHEMBL5398 | Hepatocyte nuclear factor 4-alpha | Other | Unclassified protein |
| AKT1 | Maijiedai | 0.26386963 | P31749 | CHEMBL4282 | Serine/threonine-protein kinase AKT | Kinase | Protein kinase |
| GAA | Maijiedai | 0.261304876 | P10253 | CHEMBL2608 | Lysosomal alpha-glucosidase | Enzyme | Hydrolase |
| LDLR | Maijiedai | 0.132692707 | P01130 | CHEMBL3311 | LDL receptor | Other | Membrane receptor |
| EGF | Xuanyun | 0.159065607 | P01133 | CHEMBL5734 | Pro-epidermal growth factor | Other | Unclassified protein |