Table 1.
Sirt1–3 inhibition for compounds 2a–h, 4a/4b and 8a.
| Compound | Sirt1 inhibitiona | Sirt2 inhibitiona | Sirt3 inhibitiona |
| 2a | 27% @ 50 µM | 24.6 ± 2.8 µMb | 41.7 ± 2.0 µMb |
| 2b | 71% @ 10 µM | 8.7 ± 0.2 µMb | 89% @ 50 µM |
| 2c | 51% @ 100 µM | 6.6 ± 0.5 µMb | 7.5 ± 0.9 µMb |
| 2d | 51% @ 10 µM | 64% @ 10 µM | 90% @ 50 µM |
| 2e | 61% @ 50 µM | 69% @ 50 µM | 60% @ 50 µM |
| 2f | 26% @ 10 µM | 21% @ 10 µM | 79% @ 50 µM |
| 2g | 52% @ 50 µM | 62% @ 50 µM | 87% @ 50 µM |
| 2h | n.i. | 9% @ 10 µM | n.i. |
| 4a | n.i. | 48% @ 10 µM | 38% @ 10 µM |
| 4b | n.i. | 45% @ 10 µM | 38% @ 10 µM |
| 8a | n.i. | n.i. | n.i. |
aPercent inhibition relative to controls at the indicated concentration, n.i. = no inhibition detected. bIC50 values (μM) with statistical limits; values are the mean ± SD of duplicate experiments.