Skip to main content
. 2000 Jan 1;20(1):8–21. doi: 10.1523/JNEUROSCI.20-01-00008.2000

Fig. 2.

Fig. 2.

Ampakine-induced increases in BDNF mRNA content are dose-dependent. Bar graphs show the effect of a 3 hr treatment with various concentrations of CX614 on BDNF cRNA labeling in the dentate gyrus stratum granulosum (SG), CA3 stratum pyramidale, and CA1 stratum pyramidale. Left, Graphs show mean density values for each subfield (± SEM; n = 4/group; lefty-axis applies to the stratum granulosum; righty-axis applies to CA3 and CA1). In all fields there was a significant effect of treatment (p = 0.0336 for SG;p = 0.003 for CA3; p < 0.0001 for CA1). For the granule cells, a modest increase in labeling was seen with 10 μm, and more dramatic increases were apparent with the higher doses (p < 0.05 vs control, SNK). For the pyramidal cells, only 50 μm elicited significant increases (p < 0.001 for CA3;p < 0.001 for CA1 vs control, SNK).Right, The graph shows the within-slice values for the CA3/CA1-labeling ratio (± SEM). As shown, there were significant increases in the CA3/CA1 ratio at both 10 and 20 μm(p < 0.05 and 0.03, respectively, Student's t test for comparison with controls).