Fig. 2.

CEP-1347 (500 nm) prevents hair cell loss in cochlear explants of neonatal rats exposed to 100 μm neomycin for 48 hr. A, Neomycin causes severe hair cell degeneration in the basal turn of the cochlea, as shown in phalloidin-labeled confocal images. B, CEP-1347 prevents hair cell loss in the basal turn of the cochlea.i, Inner hair cell; 1, 2, 3, rows of outer hair cells. C, Quantification of numbers of survived outer hair cells in basal and middle turns. Histograms and bars represent mean ± SEM for three experiments, each including four explants of both the control and CEP-1347 group. Scale bar:A,B, 50 μm.