Fig. 4.

CEP-1347 attenuates intense noise-induced hearing loss in vivo. Hearing threshold shifts were assessed by auditory brainstem testing 2 (A), 6 (B), and 14 (C) d after exposing control (■; n = 4 at 2 d, 8 at 6 d, 17 at 14 d) and CEP-1347-treated (⋄;n = 5 at 2 d, 11 at 6 d, 17 at 14 d) guinea pigs to noise (120 dB, 4 kHz, 6 hr). Results show mean ± SEM. Six and 14 d after exposure, the average threshold shifts of control animals are significantly greater than that of CEP-1347-treated animals. **p < 0.01; *p < 0.05; Student's t test.