Fig. 5.

CEP-1347 attenuates intense noise-induced hair cell loss in vivo. Quantification of hair cell numbers in vehicle-treated, noise-exposed control (A;n = 13) and CEP-1347-treated guinea pig cochleas (B;n = 13) 2 weeks after noise exposure (120 dB, 4 kHz, 6 hr). In the averaged cytocochleograms, the percentages of IHCs and OHCs are plotted for the entire length of the organ of Corti. Maximal damage is located in a region ∼50% from the round window. CEP-1347 treatment attenuates hair cell loss.