Table 1.
Number of preserved and lost IHCs and OHCs of different rows (OHC1, OHC2, OHC3) in CEP-1347-treated and control (CON) cochleas
Cochlea # | OHCs total | Lost hair cells | OHC loss total (%) | |||
---|---|---|---|---|---|---|
IHC | OHC1 | OHC2 | OHC3 | |||
CEP-0207 | 6897 | 1 | 40 | 27 | 38 | 105 (1.5) |
CEP-1407 | 6699 | 24 | 20 | 38 | 47 | 105 (1.6) |
CEP-0605 | 6748 | 9 | 38 | 45 | 58 | 141 (2.1) |
CEP-2203 | 6666 | 17 | 41 | 50 | 54 | 145 (2.2) |
CEP-2003 | 6585 | 19 | 53 | 37 | 64 | 154 (2.3) |
CEP-1604 | 6573 | 28 | 42 | 67 | 74 | 183 (2.8) |
CEP-2503 | 6846 | 14 | 61 | 53 | 76 | 190 (2.8) |
CEP-0307 | 6672 | 7 | 72 | 62 | 63 | 197 (3.0) |
CEP-0707 | 6387 | 6 | 74 | 74 | 56 | 204 (3.2) |
CEP-0305 | 6795 | 24 | 57 | 60 | 93 | 210 (3.1) |
CEP-2603 | 6723 | 17 | 64 | 66 | 80 | 210 (3.1) |
CEP-1101 | 6240 | 2 | 59 | 69 | 161 | 289 (4.7) |
CEP-0512 | 6454 | 25 | 180 | 198 | 229 | 607 (9.4) |
CON-2007d | 6687 | 23 | 95 | 92 | 95 | 282 (4.2) |
CON-0601 | 6423 | 2 | 65 | 149 | 114 | 328 (5.1) |
CON-0307 | 6421 | 33 | 77 | 109 | 178 | 364 (5.7) |
CON-1903d | 6480 | 77 | 89 | 136 | 141 | 366 (5.6) |
CON-2007s | 6630 | 43 | 125 | 111 | 139 | 375 (5.7) |
CON-1204 | 6897 | 56 | 102 | 139 | 184 | 425 (6.2) |
CON-1903s | 6690 | 56 | 118 | 119 | 225 | 462 (6.9) |
CON-2703 | 6507 | 77 | 205 | 117 | 184 | 506 (7.8) |
CON-0405 | 6621 | 7 | 96 | 156 | 255 | 507 (7.7) |
CON-1807 | 6621 | 7 | 96 | 156 | 255 | 507 (7.7) |
CON-0412 | 6849 | 11 | 161 | 209 | 281 | 659 (9.5) |
CON-0604 | 6882 | 78 | 156 | 222 | 341 | 719 (10.4) |
CON-0407 | 6690 | 117 | 222 | 413 | 514 | 1149 (17.2) |
Guinea pigs were exposed to 120 dB, 4 kHz noise for 6 hr. Hair cell counts were done 2 weeks after the exposure.