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. 2000 Jan 1;20(1):59–65. doi: 10.1523/JNEUROSCI.20-01-00059.2000

Fig. 5.

Fig. 5.

Persistent ω-CgTx sensitivity in glycinergic IPSCs in dorsal horn neurons of spinal cord. IPSCs were recorded in the presence of CNQX (10 μm), d-AP-5 (25 μm), and bicuculline (20 μm) and were blocked by strychnine (0.5 μm; data not shown).A, At P54, ω-CgTx (3 μm) reduced the amplitude of IPSCs by 28%. Subsequent application of ω-Aga-IVA (200 nm) blocked the remaining IPSCs. Each symbolrepresents the mean amplitude of 10 consecutive IPSCs. Sample records of 20 IPSCs before ω-CgTx application (1), after ω-CgTx application (2), and after ω-Aga-IVA application (3) were averaged and superimposed. Holding potential was −40 mV. B, The ω-CgTx-sensitive fraction at different postnatal periods. The mean ± SEMs derived from seven to eight cells (holding potentials between −40 and −70 mV) are shown in bar graphs. Data at P4–P8 are taken from Takahashi and Momiyama (1993). No significant difference between P21–P27 and P44–P54 (p = 0.281).