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. 2019 Sep 20;6(5):ENEURO.0317-19.2019. doi: 10.1523/ENEURO.0317-19.2019

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Copyright © 2019 Speed et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 6. — Behavioral and synaptic phenotypes in Shank3^G/GCre^Tam− mice are not rescued by treatment with six weeks of tamoxifen diet. Nesting behavior is not rescued by tamoxifen treatment in Shank3^G/GCre^Tam− mice with regard to nest width (A), although there is no main effect of genotype with regard to nest height (B). Marble burying (C) remains impaired in tamoxifen-treated Shank3^G/GCre^Tam− mice with decreased number of marbles buried compared to controls. Locomotor activity also remains decreased in tamoxifen-treated Shank3^G/GCre^Tam− mice at the start of the open field test (D). Latency to fall off the rotarod (E) remains decreased in tamoxifen-treated Shank3^G/GCre^Tam− mice compared to controls. Shank3^+/+ n = 25, Shank3^+/G n = 19, Shank3^G/G n = 16. F, Tamoxifen treatment does not rescue synaptic transmission in Shank3^G/GCre^Tam− mice. Inset, Average of five consecutive traces at each stimulus intensity 0–350 μA in 50-μA steps from Shank3^+/+ (top) and Shank3^G/G (bottom) mice treated with six weeks of tamoxifen diet; scale bar = 0.25 mV, 5 ms. Shank3^+/+ n = 22 slices from eight mice, Shank3^G/G n = 20 slices from six mice; *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.