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. 2019 Sep 20;6(5):ENEURO.0317-19.2019. doi: 10.1523/ENEURO.0317-19.2019

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Copyright © 2019 Speed et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 8. — Unexpected, partial genetic “rescue” of behavioral and synaptic phenotypes in vehicle-treated Shank3^G/GCre^Tam+ mice. The decreases in nest width (A) and height (B) in Shank3^G/G mice are rescued in vehicle-treated Shank3^G/GCre^Tam+ mice. The Shank3^G/Gmarble-burying phenotype (C) and initial locomotor hypoactivity in the open field test (D) are not rescued in vehicle-treated Shank3^G/GCre^Tam+ mice. E, There is no main effect of genotype in time to fall from the rotarod in vehicle-treated Shank3^GCre^Tam+ mice. Shank3^+/+ n = 26, Shank3^+/G n = 21, Shank3^G/G n = 15. F, There is no main effect of genotype on fEPSP slope in response to a range of stimulus intensities. Inset, Average of five consecutive traces at each stimulus intensity 0–350 μA in 50-μA steps from Shank3^+/+ (top) and Shank3^G/G (bottom) mice treated with vehicle diet; scale bar = 0.25 mV, 5 ms. Shank3^+/+ n = 16 slices from six mice, Shank3^G/G n = 16 slices from five mice; *p < 0.05, ***p < 0.0001, ****p < 0.00001.