Fig. 3.
Fos protein in the supraoptic and paraventricular nuclei of morphine-naïve and -dependent rats. The mean + SEM number of Fos-IR cells in the SON, the magnocellular paraventricular nucleus (MPVN), the parvocellular paraventricular nucleus (PPVN), morphine-naïve rats (NAIVE) given 0.15 m saline (VEH; subcutaneously; n = 6 or 7) or naloxone (NLX; 5 mg/kg, s.c.; n = 6) and morphine-dependent rats (DEPENDENT) given saline (VEH; subcutaneously; n = 6 or 7) or naloxone (NLX). *p< 0.05 versus morphine-naïve vehicle or naloxone-injected rats, and morphine-dependent vehicle-injected rats; one-way ANOVA on ranks, followed by Student–Newman–Keuls test.