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Chronic alprazolam decreases serum corticosterone, suggesting decreased basal activity of the HPA axis. Plasma ACTH and serum corticosterone were measured via radioimmunoassay after 14 d of incorporation of alprazolam into the diet of male Sprague Dawley rats at a concentration of 90 mg·kg−1·d−1. Eachverticalbar represents the mean ± SEM (n = 16 per group). *p < 0.05 versus controls after analysis by a two-tailed ttest.
