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. 2000 Feb 1;20(3):1036–1043. doi: 10.1523/JNEUROSCI.20-03-01036.2000

Fig. 3.

Fig. 3.

l-NAME significantly reduced microglial accumulation. In 1 mml-NAME, significantly fewer cells accumulated at the lesion site than in crushed controls (Crush) and were instead similar to uncrushed controls (data not shown). In contrast, in 1 mmd-NAME, an inactive isoform of l-NAME, microglia accumulated at the crush site in numbers equivalent to crushed control cords. For each sample nerve cord, the average number of microglia at the crush site was determined (see Materials and Methods). There was a significant difference between microglial cell accumulation at the lesion site in injured tissue treated with1 mml-NAME compared with tissue treated with 1 mmd-NAME (ANOVA; Scheffe's test;F(3,12) = 5.848; p= 0.0106; n = 4).