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. 2019 Oct 1;18:127. doi: 10.1186/s12933-019-0934-x

Table 2.

Body composition and physical fitness

AIT (n = 26) LED + AIT (n = 29) Between-group 1 yeara p
Baseline Change baseline to 1 year p Change 12 weeks to 1 year p Baseline Change baseline to 1 year p Change 12 weeks to 1 year p
Body composition
 Weight (kg) 96.2 (13.8) − 1.7 (− 0.7; − 2.6) < 0.001 − 0.4 (− 1.4; 0.6) 0.406 95.6 (10.7) − 7.2 (− 8.4; − 6.1) < 0.0 01 2.5 (1.3; 3.6) < 0.001 5.6 (4.1; 7.1) < 0.001
 Body mass index (kg/m2) 32.1 (3.2) − 0.6 (− 0.9; − 0.2) 0.001 − 0.1 (− 0.5; 0.2) 0.408 32.2 (3.1) − 2.5 (− 2.9; − 2.1) < 0.001 0.8 (0.4; 1.2) < 0.001 1.90 (1.37; 2.42) < 0.001
 Body fat mass (kg) 32.6 (7.6) − 1.9 (− 2.8; − 1.0) < 0.001 − 0.3 (− 1.2; 0,5) 0.448 34.6 (8.0) − 6.6 (− 7.7; − 5.5) < 0.001 1.9 (0.8; 3.1) < 0.001 4.7 (3.2; 6.2) < 0.001
 Body fat % 34.6 (6.5) − 1.5 (− 2.4; − 0.7) < 0.001 0.2 (− 1.0; 0.6) 0.618 36.7 (6.8) − 4.7 (− 5.8; − 3.7) < 0.001 1.6 (0.5; 2.7) 0.003 3.2 (1.8; 4.6) < 0.001
 Fat free mass (kg) 62.9 (9.9) 0.2 (− 0.5; 0.9) 0.564 − 0.3 (− 0.9; 0.4) 0.430 60.4 (8.8) − 0.5 (− 1.1; 0.02) 0.060 0.3 (− 0.2; 0.9) 0.240 0.7 (− 0.1; 1.6) 0.096
 Waist (cm) 109.9 (9.5) − 3.3 (− 5.1; − 1.5) < 0.001 − 0.4 (− 2.2; 1.4) 0.696 107.7 (7.1) − 6.6 (− 8.6; − 4.6) < 0.001 3.2 (1.2; 5.2) 0.002 3.3 (0.6; 6.1) 0.018
 Hip (cm) 110.8 (8.0) − 4.0 (− 5.1; − 2.9) < 0.001 − 1.7 (− 2.8; − 0.6) 0.003 110.3 (7.5) − 6.0 (− 7.4; − 4.7) < 0.001 0.9 (− 0.4; 2.2) 0.201 2.0 (0.3; 3.8) 0.025
 Waist/hip– ratio 0.99 (0.1) 0.005 (− 0.01; 0.02) 0.512 0.01 (− 0.003; 0.03) 0.116 0.98 (0.1) − 0.01 (− 0.03; 0.01) 0.397 0.02 (0.01; 0.02) 0.008 0.01 (− 0.01; 0.04) 0.295
Physical fitness
 VO2peaktotal (mL/min) 1997 (463) 95 (− 30; 221) 0.135 − 123 (− 249; 2) 0.053 1981 (533) 132 (37; 227) 0.007 196 (102; 292) < 0.001 − 36 (− 192; 119) 0.645
 VO2peakkg (mL/kg/min) 20.8 (4.9) 1.5 (0.2; 2.9) 0.027 − 1.0 (− 2.3; 0.4) 0.150 20.6 (5.2) 3.1 (2.9; 4.2) < 0.001 1.5 (0.4; 2.7) 0.007 − 1.6 (− 3.3; 0.2) 0.077
 VO2peakffm (mL/kg fat free mass0.67/min) 124.0 (24.3) 5.9 (− 1.9; 13.7) 0.138 − 7.4 (− 15.2; 0.4) 0.065 125.5 (25.2) 8.7 (2.8; 14.6) 0.004 11.9 (6.0; 17.9) < 0.001 − 2.8 (− 12.4; 6.9) 0.575
 Peak RER 1.19 (0.08) 0.0002 (− 0.03; 0.03) 0.989 0.01 (− 0.02; 0.04) 0.602 1.18 (0.09) 0.06 (− 0.02; 0.09) < 0.001 0.00001 (− 0.03; 0.03) 0.999 − 0.05 (− 0.1; − 0.01) 0.018
 Max workload (W) 158 (42) 13 (2; 23) 0.017 − 7.6 (− 18; 3) 0.155 155 (48) 15 (9; 22) < 0.001 15 (9; 22) < 0.001 − 2.5 (− 14.4; 9.5) 0.687
 Peak heart rate 137 (23) 1 (− 4; 7) 0.638 1 (− 6; 5) 0.826 135 (22) 9 (4; 13) < 0.001 9 (− 4; 14) < 0.001 − 7.4 (− 14.5; − 0.3) 0.040

Intention-to-treat analysis. Baseline: mean (SD) Baseline data are presented as mean (SD), within- and between-group differences are presented with 95% CI. AIT, Aerobic interval training, LED, Low energy diet, VO2peaktotal, Total peak aerobic capacity, VO2peakbw, Peak aerobic capacity corrected for body weight, VO2peakffm, Peak aerobic capacity corrected for fat free mass, CPET, Cardiopulmonary exercise test, RER, respiratory exchange ratio

aBetween-group difference at 1 year corrected for baseline difference