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. Author manuscript; available in PMC: 2019 Nov 29.
Published in final edited form as: Nature. 2019 May 29;570(7761):385–389. doi: 10.1038/s41586-019-1272-6

Extended Data Fig. 2. Germline and hematopoietic cfDNA fragment distributions.

Extended Data Fig. 2.

a, Cumulative density functions of fragment lengths at 44 loci containing germline alterations (non-tumor derived) from 38 patients with breast, colorectal, lung, or ovarian cancer are shown with 95% confidence bands. Fragments with germline mutations (orange) were comparable in length to wild-type cfDNA fragment lengths (blue). b, Cumulative density functions of fragment lengths at 41 loci containing hematopoietic alterations (non-tumor derived) from 28 patients with breast, colorectal, lung, or ovarian cancer are shown with 95% confidence bands. After correction for multiple testing, there were no significant differences (α=0.05) in the size distributions of mutated hematopoietic cfDNA fragments (orange) and wild-type cfDNA fragments (blue).