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. Author manuscript; available in PMC: 2020 Jan 15.
Published in final edited form as: Toxicology. 2018 Nov 20;412:89–100. doi: 10.1016/j.tox.2018.11.005

Figure 6.

Figure 6.

Mappings of 17α-ethynylestradiol according to the Comparative Toxicogenomics Database (http://ctdbase.org; as of July 2018). The mappings were constructed as follows: chemical-genes, literature curation; chemical-pathways, human KEGG (hsa) and REACTOME pathways enriched in chemical-genes; chemical-Gene Ontology (GO) terms, GO terms enriched in chemical-genes; chemical-disease, direct curation from the literature (4.5%) or indirect inference from transitive chemical-gene-disease associations (99%), with a slight overlap between the two methods; chemical-phenotypes (delineated by process, cellular, tissue/organ, and organism), literature curation; chemical-chemical linkages, shared gene interactions. Except for phenotypes, only top ten mappings are listed for each category. For pathways, only human KEGGs are listed.