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. Author manuscript; available in PMC: 2020 Apr 4.

Published in final edited form as: Cell. 2019 Mar 14;177(2):256–271.e22. doi: 10.1016/j.cell.2019.02.014

Figure 2. — A. Timeline of behavior experiments.

B. Recognition index of novel object recognition (NOR) test (n=20 mice no stim [black], n=20 mice 40 Hz [blue], n=9 random frequency [orange], ****P<0.0001, Kruskal-Wallis (KW) test with Dunn’s multiple comparison test).

C. Average velocity (cm/s) during novel object recognition test (n=20 mice no stim, n=20 mice 40 Hz, n=9 random frequency, KW-test with Dunn’s multiple comparison test).

D. Total distance (cm) traveled during novel object recognition test (n=20 mice no stim, n=20 mice 40 Hz, n=9 random frequency, KW-test with Dunn’s multiple comparison test).

E. Recognition index of novel object location (NOL) test of 5XFAD auditory GENUS mice (n=20 mice no stim, n=20 mice 40 Hz, n=9 random frequency, ****P<0.0001, KW-test with Dunn’s multiple comparison test).

F. Average velocity (cm/s) during novel object location test (n=20 mice no stim, n=20 mice 40 Hz, n=9 random frequency, KW-test with Dunn’s multiple comparison test).

G. Total distance (cm) traveled during novel object location test (n=20 mice no stim, n=20 mice 40 Hz, n=9 random frequency, KW-test with Dunn’s multiple comparison test).

H. Escape latencies (s) of 5XFAD mice in the Morris Water Maze (n=25 mice no stim, n=28 mice 40 Hz, n= 9 random frequency, ****P<0.0001, 2-way ANOVA with Tukey’s multiple comparison test).

I. Time (s) spent swimming in the goal quadrant during the probe trial (n=25 mice no stim, n=28 mice 40 Hz, n= 9 random frequency, *P<0.05, KW-test with Dunn’s multiple comparison test).

J. Number of platform crossings during probe trial (n=25 mice no stim, n=28 mice 40 Hz, n= 9 random frequency, **P<0.01, KW-test with Dunn’s multiple comparison test). Circles indicate ‘n’, mean +/− s.e.m. in bar graphs unless otherwise noted, n.s. = not significant.