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. 2019 Sep 25;10:1106. doi: 10.3389/fphar.2019.01106

Figure 5.

Figure 5

Activation of the B1 receptor in the microenvironment does not alter the number of colonies established. Lung metastasis was induced by the injection of B16F10 cells in the tail vein of mice, and after 5 days of cells injection, mice received des-Arg9-bradykinin (DABK) (1 mg/kg/day) for 15 days. (A) Number of melanoma colonies established in the lungs of wild-type (WT) and B1 receptor knockout mice (B1−/−) treated with DABK (WT: n = 7, B1−/−: n = 7, p = 0.28). (B) Body weight variation of wild type (WT) and B1 receptor knockout (B1-/-) mice after receiving B16F10 cells in the tail vein. (C) Histological images showing the organization of melanoma colonies established in mice lungs. ▼ indicates the presence of metastatic melanoma colonies stablished in lungs of mice.