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. 2019 Jun 19;21(7):932–942. doi: 10.1002/ejhf.1486
Primary endpoint
  • Change from baseline in 6‐min walk test distance at week 12

Key secondary endpoints
  • Change from baseline in Kansas City Cardiomyopathy Questionnaire total symptom score at week 12

  • Change from baseline in Chronic Heart Failure Questionnaire Self‐Administered Standardized format dyspnoea score at week 12

Other secondary endpoints Week 6
  • Change from baseline in 6MWT distance at week 6


Week 12
  • Change from baseline in Clinical Congestion Score at week 12

  • Change from baseline in Patient Global Impression of Severity of heart failure symptoms at week 12

  • Change from baseline in Patient Global Impression of Severity of dyspnoea at week 12

  • Patient Global Impression of Change in heart failure symptoms at week 12

  • Patient Global Impression of Change in dyspnoea at week 12

  • Change from baseline in N‐terminal pro‐brain natriuretic peptide at week 12