Figure 2.

Selective T1DM pre-clinical and clinical therapeutic intervention strategies through immunoregulation, β cell protection and regeneration, and antigenic therapy. Solid arrows denote a causal event. Dashed arrows denote cell population shift. Red arrows indicate the pathway leads to T1DM autoimmunity and green arrows indicated protective and immune tolerance pathways. Green text indicates increase secretion or strengthening of indicated molecular interaction. Red text indicates suppression of indicated molecular interaction. Purple text indicates additional therapies discussed herein.