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. Author manuscript; available in PMC: 2020 Sep 3.
Published in final edited form as: Adv Drug Deliv Rev. 2019 Sep 3;144:148–161. doi: 10.1016/j.addr.2019.08.010

Figure 3.

Figure 3.

Systems profiling of immune cell perturbations and its influence on Foreign Body Reactions and fibrosis. Using a combination of genetic knockouts and targeted immune depletions, macrophages were the only immune cell population required for fibrotic encapsulation of implanted alginate spheres. Right column: representative summary responses based on phase contrast images showing fibrosis levels on 500 μm alginate spheres retrieved from wild type C57BL/6 mice (n = 5/group), after 14-day intraperitoneal implantations. * = as reported. N/A = while available, not tested due to not being essential players. Figure and caption adapted with permission from reference [24].