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. Author manuscript; available in PMC: 2020 Sep 3.
Published in final edited form as: Adv Drug Deliv Rev. 2019 Sep 3;144:148–161. doi: 10.1016/j.addr.2019.08.010

Figure 9.

Figure 9.

Modified alginates enable successful long-term transplantation of human-derived SC-β cells in diabetic, immunocompetent mice. (a) Encapsulated SC- β cells in TMTD-alginate spheres with 1.5mm diameters. (b) The modified alginate spheres supported long-term (6 month) glycemic correction. The encapsulated cells showed signs of reduced fibrosis even at the end of the 6-month period. (c) Brightfield imaging of a retrieved sphere with encapsulated SC-β cell cluster seen inside. (d) Immunofluorescence straining, (e) Masson’s trichrome, and (f) H&E histology of the retrieved spheres. Figure and caption adapted with permission from reference [119].