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. 2019 Sep 25;13:1020. doi: 10.3389/fnins.2019.01020

TABLE 2.

Stereological determination of Egr-1–positive cell density on the left and right hemispheres at the infragranular layers of the somatosensorial cortex for 2 and 6 h of recording of the induction of cortical spreading depression (CSD) in adult rats.

Group Animal Egr-1 cell SCE Thickness Egr-1 cell SCE Thickness
density RH RH RH density LH LH  LH
2 h recording High number of CSD episodes 4 77,075.12 0.04 28.30 163,850.09 0.03 29.16
6 66,525.43 0.04 29.57 104,606.94 0.03 30.16
14 67,778.58 0.04 27.92 147,191.29 0.03 28.99
24 122,969.38 0.03 28.61 110,417.15 0.03 29.72
13 63,254.55 0.06 27.05 98,960.69 0.04 28.41
15 75,121.43 0.05 24.15 109,653.23 0.04 26.97
Mean 78,787.53 0.04 27.60 122,446.563 0.03 28.90
SD 22,276.52 0.009 1.87 26,475.53 0.006 1.12
2 h recording Low number of CSD episodes 3 79,707.50 0.06 26.25 128,828.49 0.05 34.47
11 63,274.85 0.05 25.06 105,694.41 0.05 25.45
29 65,865.10 0.05 29.92 81,687.37 0.04 31.08
31 78,962.42 0.04 31.23 97,698.16 0.04 29.79
34 56,375.91 0.05 29.87 87,055.36 0.04 29.87
Mean 68,837.16 0.05 28.47 100,192.76 0.04 30.13
SD 10,194.86 0.005 2.66 18,517.14 0.006 3.23
6 h recording High number of CSD episodes 18 119,353.3238 0.04 31.08 79,166.98099 0.06 31.34
20 159,225.4106 0.04 29.97 146,291.4382 0.04 31.08
26 87,300.06771 0.05 29.58 103,398.8471 0.04 30.30
27 118,105.1301 0.03 28.67 128,295.7078 0.03 28.14
28 127,835.8445 0.04 30.51 119,502.0794 0.04 29.42
Mean 122,363.9553 0.04 29.96 115,331.0107 0.04 30.05
SD 25,716.66 0.006 0.92 79,166.98099 0.010 1.31
6 h recording Low number of CSD episodes 29 rep 79,578.4467 0.03 30.55 77,361.2809 0.04 29.78
30 78,495.4937 0.04 30.44 82,902.15573 0.04 29.22
32 78,738.9635 0.04 29.75 92,226.46693 0.04 30.37
33 55,357.8865 0.05 29.09 69,011.61588 0.04 30.58
39 73,257.0813 0.04 28.65 59,969.65573 0.05 28.03
Mean 73,085.5743 0.04 29.69 76,294.24 0.04 29.60
SD 10,218.68 0.007 0.83 12,431.4887 0.004 1.023
2 h recording Sham 9 72,696.24085 0.04 29.67 72,243.4081 0.04 27.29
10 72,077.6669 0.04 26.75 66,980.1333 0.04 28.15
19 69,493.47595 0.04 30.02 53,485.9831 0.05 29.17
Mean 71,422.46124 0.04 28.81 64,236.5081 0.04 28.20
SD 8,698.9398 0.0015 1.80 9,675.012 0.003 0.94
6 h recording Sham 36 59,427.30555 0.04 27.29 89,995.3672 28.49 0.04
37 57,573.96491 0.04 28.15 73,798.953 29.19 0.04
38 46,997.21448 0.05 29.17 51,662.4134 29.55 0.04
Mean 54,666.16165 0.04 28.20 71,8189112 29.08 0.04
SD 6,705.84 0.003 0.94 19,243.0315 0.54 0.005

2 and 6 h; 2 and 6 h of recording; high and low number, high and low number of CSD episodes; sham, zero episodes; LH and RH, left and right hemispheres; SCE, Schaeffer coefficient error; SD, standard deviation.