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. 2019 Oct 2;39(40):7826–7839. doi: 10.1523/JNEUROSCI.0105-19.2019

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Figure 8. — Modeling SK channel interactions with voltage-activated calcium channels. A, Impact of varying the SK channel conductance (gSK) density on membrane potential. B, Impact of varying gSK on availability of calcium channels. C, E, Calcium spikes evoked by brief current injections (50 ms; 200 pA) in the presence (black) and absence (red) of SK channels (2 pS/μm²) in models with the voltage-activated calcium channel conductance density (gCa) set to 150 pS/um² (C) or 15 pS/um² (E). D, F, Amplitude of voltage responses to brief (50 ms) current injections of different amplitude in the presence (black) and absence (red) of SK channels (2 pS/μm²) in models with gCa set to 150 ps/μm² (D) or 15 pS/μm² (F). G, Ratio of calcium spike amplitude in models with SK channels present (SK ON) or absent (SK OFF) versus the gSK density in models with different gCa densities. Calcium spikes evoked by brief current injections (50 ms; 200 pA). Ratios greater than one (dotted line) indicate an excitatory action of SK channels. H, Amplitude of calcium spikes evoked by brief current injections (50 ms; 200 pA) versus gCa in models with different gSK densities.