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. 2019 Oct 2;39(40):7934–7946. doi: 10.1523/JNEUROSCI.0006-19.2019

Figure 2.

Figure 2.

CRH-1c and e are required for associative learning in C. elegans. A, Schematic showing C. elegans CRH-1 and the deletion in the mutant. Two major functional domains KID and bZIP (DNA-binding domain) domains are depicted. The red bar shows the deletion found in the crh-1-null mutant tz2. This deletion affects all CRH-1 isoforms. B, Scatter plot showing chemotaxis indices of WT and crh-1-null mutants. C, Graph showing quantitative PCR results comparing mRNA expression levels of different CRH-1 isoforms to the CRH-1e isoform in young adult WT C. elegans. D, Scatter plot showing chemotaxis indices of WT, crh-1-null mutants, and pan-neuronal CRH-1 rescue lines using different crh-1 isoforms. E, Scatter plot showing chemotaxis indices of WT, crh-1-null mutants and crh-1 isoform deletion lines. Error bars are SD. Multiple comparisons were done using one-way ANOVA and p values were adjusted using Bonferroni (B, D, E) and Dunnett's (C) methods. Data points represented with dark blue dots in the scatter plots represents outliers identified using Grubb's method (α = 0.05). **p < 0.01, ***p < 0.001, ns, p > 0.05.