Figure 6.
Amyloid plaque load is reduced in brain sections by genetic inactivation of PI3Kδ. A, Representative photomicrographs of hippocampal sections from mice of different genotypes stained for Aβ plaques using Thioflavin S. B, C, Quantification of plaque number (B) and size (C) in the hippocampus of APP/PS1 and APP/PS1/δD910A mice. D, Representative photomicrograph of cortical sections stained with Thioflavin S. E, F, Quantification of plaque numbers (E) and area covered by plaques (F) in the cortex of experimental mice. Scale bar represents 100 μm. Data are displayed as mean ± SEM, n = 4 animals aged 6.5-months-old per genotype and 3 replicates per animal (each replicate is a different section from the same brain region i. e. hippocampus or cortex), Student's t test, *p < 0.05, **p < 0.01. The statistical power of the results is specified in the Figure 6-1.