Table 2.
Published studies reviewed.
| Author, Publication Date | Patients (no.) | Patients with NF (no.) | Total Lesions (no.) | Lesions by Histology (no.) | Radiation Delivery | Prescription Dose, % Isodose Line | Fractionation | Median Follow-up (months) | Outcomes | Radiation Toxicities (no. patients) |
| Gerszten P, 2003 [16] | 15 | NR | 15 | 2 Meningiomas 25 Schwannomas 5 Neurofibromas |
CyberKnife | 1200 - 2000 cGy, 80% | 1 | mean 12 | 100% LC | None |
| Dodd R, 2006 [42] | 51 | 17 | 55 | 16 Meningiomas 30 Schwannomas 9 Neurofibromas |
CyberKnife | 1600 - 3000 cGy, 80% | 1 - 5 | 23 | 95% LC | 1 Radiation Myelopathy |
| Sahgal A, 2007 [35] | 16 | 3 | 19 | 2 Meningiomas 0 Schwannomas 11 Neurofibromas |
CyberKnife | Median 2100 cGy, 80% | 3 | 25 | 12 month FFP**: 89% 3-year FFP**: 71% |
1 Nausea |
| Gerszten P, 2008 [17] | 73 | 30 | 73 | 13 Meningiomas 35 Schwannomas 25 Neurofibromas |
CyberKnife | 1500 - 2500 cGy, 80% | 1 - 3 | 37 | 100% LC 73% PC |
3 Brown-Sequard syndrome |
| Murovic J, 2009 [66] | 15 | 3 | 17 | 0 Meningiomas 10 Schwannomas 7 Neurofibroma |
CyberKnife | 1600 - 2400 cGy | 1 - 3 | 6 - 72 | 76% LC 85% PC 86% NC |
None |
| Selch M, 2009 [36] | 20 | 8 | 25 | 0 Meningiomas 8 Schwannomas 8 Neurofibromas |
LINAC | 1200 - 1500 cGy, ≥90% | 1 | 18 | 100% LC 100% NC |
None |
| Sachdev S, 2011 [25] | 87 | 25 | 103 | 32 Meningiomas 47 Schwannomas 24 Neurofibromas |
CyberKnife | 1400 - 3000 cGy |
1 - 5 | 29 | 98% LC 67-100% PC 67-91% NC |
1 Transient Myelitis |
| Gerszten P, 2012 [69] | 45 | 9 | 45 | 10 Meningiomas 16 Schwannomas 14 Neurofibromas | LINAC (Synergy S) | 1600 cGy | 1 - 3 | 32 | 100% LC 79% PC*** 93% NC |
None |
| Kufeld M, 2012 [34] | 36 | 3 | 36 | 11 Meningiomas 25 Schwannomas |
CyberKnife | 1340 - 1400 cGy, 70% | 1 | 18 | 100% LC 97-100% PC 100% NC |
1 Transient Myelitis |
| Niazi T, 2012 [67] | 1 | 0 | 1 | 0 Meningiomas 1 Schwannomas 0 Neurofibromas |
LINAC | 1500 cGy, 90% | 1 | 15 | Stable Disease | None |
| Marchetti M, 2013 [23] | 18 | 5 | 21 | 11 Meningiomas 9 Schwannomas 1 Neurofibroma |
CyberKnife | 1160 - 2270 cGy, 95% | 1 - 6 | 38 | 100% LC 79% PC 79% NC |
1 Sciatalgia 1 Nausea |
| Lee M, 2015 [37] | 11 | NR | 11 | 11 Meningiomas | Median 1500 cGy - 2600 cGy | 1 - 3 | 46.9 | 100% LC | None | |
| Shin DW, 2015 [49] | 58 | 7 | 110 | 47 Schwannomas | LINAC | Median 1300 cGy | 1 | 44 | 95% LC 100% PC 100% NC |
None |
| Kalash R, 2018 [28] | 38 | NR | 47 | 15 Meningiomas 13 Schwannomas |
CyberKnife LINAC |
900 - 2100 cGy | 1 - 3 | 54 | 76% LC | None |
| Elibe R, 2018 [33] | 9 | NR | 9 | 4 Meningiomas 3 Schwannomas |
LINAC | 1000 - 2400 cGy, 90% | 1 | 13 | 77% LC^ 88% PC^ 65% NC^ |
No toxicity after treatment of benign lesions |
Key: NF = Neurofibromatosis, M = Meningioma, S = Schwannoma, N = Neurofibroma, LC = Local Control, PC = Pain Control, NC = Neurologic Control, NR = Not Reported
*
Range,
**
Actuarial Kaplan Meier (excluding previously irradiated lesions),
***
Pain Improvement, ^ mixed results of treated benign and malignant lesions