Skip to main content
. 2019 Oct 2;14(10):e0223435. doi: 10.1371/journal.pone.0223435

Fig 3. Dietary polyphenols of BDPP alleviated the painful behavior associated with IVD injury.

Fig 3

(A) Hindpaw mechanical hyperalgesia was measured using the von Frey test, where a decreased hindpaw withdrawal threshold indicates enhanced sensitivity to pain. (B) Changes of pain sensitivity across the duration of the study. Presented are withdrawal thresholds normalized to baseline (pre-op) values. Line plots present normalized group mean (±SEM) withdrawal threshold values of individual experimental treatment groups. * indicates P<0.05 from Pre-op. (C) and (D) Normalized withdrawal thresholds at 1-week & 6-week post-surgery, respectively. Scatter plots present withdrawal thresholds of individual animals across the experimental groups (n = 12 for Naïve, n = 14 for Sham, n = 14 for Injury & n = 14 for BDPP). Cross bars present group mean and SEM withdrawal thresholds. * indicates P<0.05 between groups.