Table 1. .

The superiority of IMPT in dose distribution, toxicity and efficacy

Parameter	Superiority of IMPT	Reference
Dose distribution	I. More accurate dose coverage with respect to tumor area II. Lower doses exposure to the normal tissues III. Effective delivery of the dose to the target	17–21
Toxicity	I.Better protection of OAR II. Fewer acute and chronic toxicities	17,20,22
Efficacy	I.Satisfactory local control rate II. Satisfactory disease-free survival * No clinical trials compared the survival outcome between IMRT and proton IMPT directly.	23,24

IMPT, intensity modulated proton therapy; IMRT, intensity modulated radiotherapy; OAR, organ at risk.