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. Author manuscript; available in PMC: 2020 Mar 11.
Published in final edited form as: Nature. 2019 Sep 11;573(7774):416–420. doi: 10.1038/s41586-019-1549-9

Extended Data Figure 9. Most frequent YKOC mutations and their distributions between different source laboratories.

Extended Data Figure 9

Most frequent mutations, with predicted effects on genes, detected in the YKOC (top 200) and their distribution among different source laboratories. (a) Left: the mutation is indicated by its predicted effect, and the background indicates whether it is a mutation in a gene with degenerate repeats (grey), a mutation coming from founder effect (yellow), or a frequently mutated site (green); boldface indicates homozygous mutation. Centre: heatmap of the distribution of the most frequent mutations by laboratory in which the strain carrying that mutation was produced (100% indicates that all the strains with a certain mutation were generated in the same laboratory). Right: number of strains carrying the mutation. (b) Not all strains derived from each laboratory share founder mutations: as in (a), but a value of 100% in the heatmap indicates that all the strains generated by a certain laboratory have that mutation.