Table.
Baseline Characteristics of Participants Enrolled in AREDS2 Cataract Study
| Baseline Characteristic | Primary Randomized Treatment, No. (%) | |||
|---|---|---|---|---|
| Placebo (n = 775) | Lutein/Zeaxanthin (n = 787) | DHA/EPA (n = 803) | Lutein/Zeaxanthin+DHA/EPA (n = 794) | |
| Race | ||||
| White | 741 (95.6) | 765 (97.2) | 765 (95.3) | 767 (96.6) |
| Black | 13(1.7) | 5 (0.6) | 17(2.1) | 12 (1.5) |
| Other mixed race | 21(2.7) | 17 (2.2) | 21 (2.6) | 15 (1.9) |
| Ethnicity | ||||
| Hispanic | 11(1.4) | 12 (1.5) | 19 (2.4) | 24 (3.0) |
| Age at randomization, median (IQR), y | 72 (66–77) | 72 (66–77) | 72 (66–77) | 72 (66–78) |
| Female | 414(53.4) | 435 (55.1) | 435 (54.2) | 455 (57.3) |
| Educationa | ||||
| Grade 11 or less | 44 (5.8) | 49 (6.3) | 53 (6.7) | 42 (5.4) |
| High school graduate | 196 (25.8) | 176 (22.8) | 198 (25.2) | 190 (24.3) |
| Some college or associate’s degree | 197 (25.9) | 216 (27.9) | 226 (28.8) | 215 (27.5) |
| Bachelor’s degree | 150 (19.7) | 165 (21.4) | 131 (16.7) | 171 (21.9) |
| Postgraduate degree | 174 (22.9) | 167 (21.6) | 178 (22.6) | 164 (21.0) |
| Diabetes mellitus status | 106 (13.7) | 84 (10.7) | 107 (13.3) | 103 (13.0) |
| Smoking status | ||||
| Never | 312 (40.3) | 356 (45.2) | 350 (43.6) | 362 (45.6) |
| Former | 412 (53.2) | 373 (47.4) | 400 (49.8) | 384 (48.4) |
| Current | 51 (6.6) | 58 (7.4) | 53 (6.6) | 48 (6.0) |
| Lens statusb | ||||
| Bilateral phakia | 716 (92.4) | 709 (90.1) | 730 (90.9) | 721 (90.8) |
| Unilateral pseudophakia | 59 (7.6) | 78 (9.9) | 73 (9.1) | 73 (9.2) |
| Cortical opacity present | 316 (43.5) | 288 (39.6) | 303 (40.5) | 332 (44.8) |
| Posterior subcapsular cataract present | 58 (8.0) | 57 (7.8) | 54(7.2) | 60 (8.1) |
| Dietary lutein/zeaxanthin, μg/d/1000 kcal | ||||
| Median | 2725 | 2590 | 2553 | 2572 |
| Quintile 1 range | 121–1466 | 245–1385 | 304–1467 | 43–1455 |
| Quintile 5 range | 4755–38 110 | 4825–34 398 | 4627–21 513 | 4489–39 790 |
Abbreviations: AREDS2, Age-Related Eye Disease Study 2; DHA, docosahexaenoic acid; EPA, eicosapentaenoic acid; IQR, interquartile range.
a
Fifty-seven participants refused to answer.
b
Missing lens gradings: cortical, 216 participants; posterior subcapsular cataract, 219 participants.