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. Author manuscript; available in PMC: 2019 Oct 2.
Published in final edited form as: Clin Cancer Res. 2019 Jun 21;25(19):5984–5996. doi: 10.1158/1078-0432.CCR-18-3399

Figure 3. FGTI-2734 induces apoptosis in mutant KRAS-dependent, but not independent, human cancer cell lines with different oncogenic KRAS mutation.

Figure 3.

A, mutant KRAS harboring MiaPaCa2, L3.6pl, and Calu6 (mutant KRAS-dependent cell lines). B, mutant KRAS harboring A549, H460, and DLD1 (mutant KRAS-independent cell lines). For both panels, cells were transiently infected with lentiviral guide RNAs (gRNA) of scrambled (SC) and KRAS gRNAs and treated with either vehicle (DMSO) or indicated concentrations of FGTI-2734 followed by Western blot analysis with indicated antibodies.