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. Author manuscript; available in PMC: 2020 Apr 1.
Published in final edited form as: Mol Cancer Res. 2019 Jul 10;17(10):2042–2050. doi: 10.1158/1541-7786.MCR-19-0309

Figure 4: Genomic context of differentially methylated probes shows enrichment for open sea regions of the genome and CpG Island shores near transcription start sites.

Figure 4:

A, Fraction of CpG sites identified as differentially methylated with change in Beta value ≤−0.2 concurrent in all three IDH1−/WT clones of IMA and no corresponding change in Beta value ≤−0.2 in either unedited clone. Plotted in blue is the frequency of CpG sites within each genomic context on the EPIC array. Chi-squared goodness of fit p-value for difference from expected background frequency < 2.2x10^−16 B, Similar enrichment plot for 08-0537 using change in Beta value ≤−0.2 in the clone with loss of heterozygous IDH1R132H/WT status and removing probes showing a delta Beta value ≤−0.2 change in matched unedited control clone. Chi-squared goodness of fit p-value for difference from expected background frequency < 2.2x10^−16.