Table 1:

Classification of BRAF mutations

BRAF Class	BRAF mutation	Kinase activity	Potential targets
Class I	V600	RAS-independent	BRAFi or BRAFi/MEKi combination
Class II	non-V600	RAS and RTK independent	MEKi, ERKi or paradoxical blocking BRAFi
Class III	N581, D594	No kinase activity, CRAF activation.	MEKi+ RTK inhibitors