Table 4:

Risk of type 1, type 2, and high-grade serous ovarian cancer by trauma exposure and PTSD symptoms, Nurses’ Health Study II, 1989-2015 (N=49 443, N type 1=39, N type 2=70, N high-grade serous=58)^†

	Type 1 cancers		Type 2 cancers		High-grade serous cancers
	Adjusted for age		Adjusted for age		Adjusted for age
	Cases/person- years	Hazard Ratio (95% CI)	Cases/person- years	Hazard Ratio (95% CI)	Cases/person- years	Hazard Ratio (95% CI)
Trauma and PTSD
No trauma	10/284 582	1.0 [Reference]	15/284 582	1.0 [Reference]	11/284 505	1.0 [Reference]
Trauma, no PTSD	5/288 658	0.42 (0.14, 1.22)	15/288 658	0.81 (0.40, 1.67)	13/288 619	0.96 (0.43, 2.15)
1-3 PTSD symptoms	8/287 873	0.64 (0.25, 1.62)	17/287 873	0.90 (0.45, 1.80)	13/287 851	0.95 (0.42, 2.13)
4-5 PTSD symptoms	7/122 473	1.32 (0.75, 3.49)	9/122 473	1.13 (0.49, 2.6)	8/122 450	1.39 (0.56, 3.48)
6-7 PTSD symptoms	6/70 480	2.08 (0.75, 5.77)	10/70 480	2.12 (0.95, 4.75)	9/70 480	2.64 (1.09, 6.42)*
Test of trend		p=0.10†		p=0.11†		p=0.05†
Trauma, PTSD symptoms unknown	3/103 360	1.11 (0.29, 4.19)	4/103 360	1.99 (0.62, 6.40)	4/103328	2.38 (0.71, 7.93)

^*p<0.05

^†Type 1 cancers include, grade 1 serous, mucinous, endometrioid, clear cell, and grade 1 mixed. Type 2 cancers include grades 2, 3 and unknown grade serous, poorly differentiated, transitional/Brenner, carcinosarcoma, and grades 2 and 3 mixed. In each analysis, women who developed other ovarian cancer types were considered non-cases and were censored at the time of their diagnosis.

Person-time when PTSD symptoms were unknown was excluded from the test of trend.