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. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Cell Metab. 2019 Aug 22;30(4):656–673. doi: 10.1016/j.cmet.2019.07.011

Figure 3. Therapeutic perspectives for extracellular miRNAs.

Figure 3.

Circulating EV-associated miRNAs are profiled in patients to identify differentially expressed molecules. These candidates are tested in pre-clinical studies and miRNAs that play a role in disease are selected for clinical trials. Clinically relevant miRNA mimics or antimiR molecules are loaded into the patient’s own EVs and reinjected in the blood stream to restore EV miRNA levels to normal.