Table 3.
Associations between PBDE serum concentrations and risk of papillary thyroid cancer in 250 cases and 250 controls.
| PBDE Congener (ng/g)a | Controls | Cases | Unadjusted OR (95%CI) | Adjusted ORb (95%CI) |
|---|---|---|---|---|
| BDE-28 | ||||
| ≤0.51 | 125 | 147 | 1 | 1 |
| >0.51 to ≤1.65 | 100 | 78 | 0.66 (0.45–0.97) | 0.67 (0.45–1.00) |
| >1.65 | 25 | 25 | 0.85 (0.47–1.56) | 0.87 (0.46–1.65) |
| Continuous | 250 | 250 | 0.96 (0.81–1.15) | 0.94 (0.78–1.13) |
| BDE-47 | ||||
| ≤7.28 | 125 | 139 | 1 | 1 |
| >7.28 to ≤24.91 | 100 | 90 | 0.81 (0.56–1.18) | 0.80 (0.54–1.18) |
| >24.91 | 25 | 21 | 0.76 (0.40–1.42) | 0.66 (0.34–1.28) |
| Continuous | 250 | 250 | 0.91 (0.74–1.18) | 0.89 (0.72–1.10) |
| BDE-85 | ||||
| <LOD | 161 | 176 | 1 | 1 |
| ≥LOD | 89 | 74 | 0.76 (0.52–1.11) | 0.71 (0.48–1.05) |
| Continuousc | - | - | - | - |
| BDE-99 | ||||
| ≤1.21 | 125 | 138 | 1 | 1 |
| >1.21 to ≤5.00 | 100 | 94 | 0.85 (0.59–1.23) | 0.83 (0.56–1.21) |
| >5.00 | 25 | 18 | 0.65 (0.34–1.25) | 0.57 (0.29–1.12) |
| Continuous | 250 | 250 | 0.93 (0.76–1.14) | 0.91 (0.74–1.12) |
| BDE-100 | ||||
| ≤1.47 | 125 | 138 | 1 | 1 |
| >1.47 to ≤5.43 | 100 | 91 | 0.82 (0.57–1.20) | 0.78 (0.53–1.15) |
| >5.43 | 25 | 21 | 0.76 (0.41–1.43) | 0.73 (0.38–1.41) |
| Continuous | 250 | 250 | 1.07 (0.89–1.29) | 1.05 (0.87–1.26) |
| BDE-153 | ||||
| ≤3.08 | 125 | 130 | 1 | 1 |
| >3.08 to ≤14.02 | 100 | 88 | 0.85 (0.58–1.23) | 0.85 (0.58–1.26) |
| >14.02 | 25 | 32 | 1.23 (0.69–2.19) | 1.19 (0.66–2.16) |
| Continuous | 250 | 250 | 1.08 (0.90–1.29) | 1.08 (0.90–1.30) |
| BDE-154 | ||||
| <LOD | 152 | 164 | 1 | 1 |
| ≥LOD | 98 | 86 | 0.81 (0.57–1.17) | 0.78 (0.53–1.13) |
| Continuousc | - | - | - | - |
| BDE-183 | ||||
| <LOD | 176 | 185 | 1 | 1 |
| ≥LOD | 74 | 65 | 0.84 (0.57–1.24) | 0.74 (0.49–1.12) |
| Continuousc | - | - | - | - |
| BDE-209 | ||||
| ≤1.55 | 125 | 136 | 1 | 1 |
| >1.55 to ≤4.08 | 100 | 100 | 0.92 (0.64–1.33) | 0.90 (0.61–1.32) |
| >4.08 | 25 | 14 | 0.52 (0.26–1.03) | 0.47 (0.23–0.98) |
| Continuous | 250 | 250 | 0.90 (0.75–1.09) | 0.87 (0.71–1.06) |
| BB-153 | ||||
| ≤1.45 | 125 | 129 | 1 | 1 |
| >1.45 to ≤3.51 | 100 | 89 | 0.86 (0.59–1.26) | 1.16 (0.76–1.76) |
| > 3.51 | 25 | 32 | 1.24 (0.70–2.21) | 1.81 (0.96–3.39) |
| Continuous | 250 | 250 | 1.05 (0.87–1.27) | 1.15 (0.88–1.52) |
a
Categories established based on distributions among controls and correspond to either (i) ≤median, >median and ≤90th percentile, and >90th percentile for congeners with detection frequency ≥80% (ii) undetected versus detected samples for congeners with detection frequency <80%.
b
Adjusted for age, alcohol consumption, and years of education.
c
Continuous models not run when detection frequency was <80%.
LOD, limit of detection