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. Author manuscript; available in PMC: 2020 Apr 1.
Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2019 Jul 10;28(10):1735–1745. doi: 10.1158/1055-9965.EPI-19-0066

Figure 3. Analysis of Individual Risk Loci and Tissue-specific Regulatory Elements.

Figure 3.

ChIP-Seq data and Roadmap segmentations (subset for enhancers) were used to examine the significance of overlap with CRV risk spans for each of the 142 BCa risk loci (columns). Significance levels are depicted in red with darker red indicating a greater risk-span/RE overlap proportion compared to background levels for that locus. Dendrograms are based on complete linkage using city-block distance measurements of −log(p.value). The individual loci showing the most significant overlap are identified by chromosome and position underneath. These are the loci with the most specific correspondence between tissue-specific regulatory elements and BCa CRVs.