Table I.
Characteristics of twenty-four studies on only paediatric patients (clinical trials, reviews and registries/surveys).
| Ref. (n) | Authors | Year | Type of haemophilia | Patients (*n) | Age of patients | ICH (n) |
|---|---|---|---|---|---|---|
| 23 | Chalmers et al. | 2018 | A/B | 54 | ≤2yrs | 54 |
| 20 | Andersson et al. | 2017 | A/B | 1,515 | ≤22yrs | 60 |
| 16 | Kulkarni et al. | 2017 | A/B | 547 | ≤2yrs | 46 |
| 22 | Bladen et al. | 2016 | A/B | 283 | 0–16+ yrs | 26 |
| 17 | Nazir et al. | 2016 | A | 163 | 2 wks–18 yrs | 5 |
| 18 | Davies et al. | 2016 | A/B | 3,018 | 0–30 days | 79 |
| 27 | Liu et al. | 2015 | A | 70 (total) | 1–18 yrs | 1 |
| 19 | Witmer | 2015 | A/B | 3,133 | <21 yrs | 271 |
| 28 | Moorehead et al. | 2013 | A | 58 | 0–30 days | 9 |
| 29 | Morales et al. | 2013 | A | 10 | NA | 10 |
| 24 | Nagel et al. | 2013 | A/B | NA | 3–18 yrs | |
| 25 | Richards et al. | 2012 | A/B | 508 | NA | 4 |
| 21 | Patiroglu et al. | 2011 | A/B | 7 | 3 wks–13 yrs | 7 |
| 30 | Kenet et al. | 2010 | A/B | 864 | 0–2 yrs | 49 |
| 31 | Kulkarni et al. | 2009 | A/B | 580 | 0–2 yrs | |
| 32 | Bladen et al. | 2009 | A | 6 | 4–12 yrs | 6 |
| 33 | Mishra et al. | 2008 | A/B | 38 | 0–22 yrs | |
| 34 | Smith et al. | 2008 | A/B | 20 | 0–7 days | 3 |
| 35 | Traivaree et al. | 2007 | A/B | 43 | 0–17 yrs | 11 |
| 36 | Tarantino et al. | 2007 | A/B | 580 | NA | 17 |
| 37 | Revel-Vilk et al. | 2004 | A/B | 172 | 0–3 yrs | 18 |
| 38 | Kulkarni et al. | 1999 | A/B | NA | NA | |
| 39 | Nelson et al. | 1999 | A/B | NA | NA | |
| 15 | Kulkarni et al. | 1999 | A/B | 102 | 0–1 month | 109 |
| Total | 11,669§ | 676§ |
ICH: Intracranial haemorrhage; NA: not available; wks: weeks; yrs: years.
*
Only patients with haemophilia A or B.
§
Cumulative number, including the reviews; cases may be repeated among different reports.