Table 1.
General clinical characteristics for all enrolled cases
| Case | Gender | Age (years) | Involved organ/tissue | Subtypes | Biopsy site | BRAFV600E status | Treatment | Outcomes |
|---|---|---|---|---|---|---|---|---|
| 1 | M | 43 | Lung | SS | VATS lung biopsy | WT | Quit smoking | Cured |
| 2 | M | 15 | Pituitary | SS | surgical pituitary biopsy | WT | Radiotherapy | Improved |
| 3 | M | 17 | Maxillary sinus | SS | surgical maxillary sinus mass biopsy | WT | Surgery | Cured |
| 4 | M | 22 | Lung, pituitary, mandible, vertebrae | MS‐RO− | VATS lung biopsy, mandible biopsy | WT | Chemotherapy | Relapse |
| 5 | F | 36 | Pituitary, mandible | MS‐RO− | Surgical pituitary biopsy | WT | Radiotherapy | Improved |
| 6 | F | 2 | Skull, pituitary | MS‐RO− | Surgical skull biopsy | V600E | Chemotherapy | Improved |
| 7 | F | 12 | Lung, liver, pituitary | MS‐RO+ | Surgical hepatic biopsy | WT | Chemotherapy | Improved |
| 8 | M | 51 | Lung, pituitary | MS‐RO− | VATS lung biopsy | WT | Chemotherapy | Improved |
| 9 | M | 73 | Lymph nodes, skin | MS‐RO− | Surgical lymph node biopsy | WT | Chemotherapy | Improved |
| 10 | M | 12 | Left humerus | SS | Surgical bone biopsy | WT | Surgery, radiotherapy | Improved |
| 11 | M | 55 | Lung, oral mucosa, lymph node | MS‐RO− | Surgical mucosa biopsy | V600E | Chemotherapy | Improved |
| 12 | M | 37 | Femur | SS | Surgical bone biopsy | WT | Surgery | Cured |
| 13 | M | 26 | Lung, vertebrae, liver, pituitary | MS‐RO+ | Surgical bone and liver biopsy | WT | Chemotherapy, liver transplantation | Relapse |
| 14 | M | 15 | Lung, pituitary, thyroid | MS‐RO− | Surgical thyroid resection | WT | Surgery, chemotherapy | Improved |
| 15 | M | 39 | Pituitary | SS | Surgical pituitary biopsy | WT | Radiotherapy, surgery | Improved |
| 16 | M | 13 | Pituitary | SS | Surgical pituitary biopsy | WT | Surgery | Improved |
| 17 | M | 37 | Lung, thyroid | MS‐RO− | Thyroid fine needle biopsy | WT | Chemotherapy | Improved |
| 18 | M | 5 | Vertebrae | SS | Surgical bone biopsy | V600E | Surgery | Cured |
| 19 | F | 6 | Vertebrae | SS | Surgical bone biopsy | V600E | Surgery | Cured |
| 20 | F | 9 | Pituitary | SS | Surgical pituitary biopsy | WT | Surgery, radiotherapy | Improved |
| 21 | F | 14 | Pituitary, vertebrae, skin | MS‐RO− | Surgical bone biopsy | WT | Surgery, chemotherapy | Improved |
| 22 | F | 25 | Pituitary | SS | Surgical pituitary biopsy | WT | Surgery, radiotherapy | Improved |
| 23 | F | 43 | Skull | SS | Surgical bone biopsy | WT | Surgery, chemotherapy | Improved |
| 24 | M | 76 | Multiple lymph nodes | MS‐RO− | Surgical lymph node biopsy | WT | Chemotherapy | Exacerbation |
| 25 | M | 42 | Lung, mandible | MS‐RO− | Surgical mandible biopsy | V600E | Chemotherapy | Improved |
| 26 | M | 17 | Skull, femur, pituitary | MS‐RO− | Surgical bone biopsy | V600E | Chemotherapy | Improved |
| 27 | M | 12 | Skull, femur, vertebrae, pituitary | MS‐RO− | Surgical bone biopsy | WT | Chemotherapy | Improved |
| 28 | M | 43 | Pituitary, vertebrae, tibia | MS‐RO− | Surgical bone biopsy | V600E | Chemotherapy | Improved |
| 29 | M | 12 | Vertebrae | SS | Surgical bone biopsy | WT | Surgery, radiotherapy | Improved |
| 30 | F | 49 | Lung, pituitary, liver, lymph node | MS‐RO+ | VATS lung biopsy, skin biopsy | WT | Chemotherapy | Improved |
| 31 | M | 28 | Lung, pituitary, skin | MS‐RO− | VATS lung biopsy | WT | Chemotherapy | Improved |
| 32 | F | 17 | Lung, pituitary, skin, lymph node | MS‐RO− | Skin biopsy | WT | Chemotherapy | Relapse |
| 33 | M | 21 | Lung, thyroid, pituitary, liver, lymph node | MS‐RO+ | Thyroid fine needle biopsy | WT | Chemotherapy, thyroid radiotherapy | Improved |
| 34 | M | 15 | Pituitary, liver, lymph node | MS‐RO+ | Liver fine needle biopsy | WT | Chemotherapy | Improved |
| 35 | M | 8 | Lung, thyroid, pituitary, lymph node | MS‐RO− | Thyroid fine needle biopsy | WT | Chemotherapy | Improved |
| 36 | M | 24 | Lung, skull, pituitary, skin, stomach | MS‐RO− | Stomach and skin biopsy | V600E | Chemotherapy | Exacerbation |
| 37 | F | 14 | Skull, pituitary | MS‐RO− | Surgical bone biopsy | WT | Surgery, chemotherapy | Improved |
| 38 | M | 20 | Pituitary, skin | MS‐RO− | Skin biopsy | WT | Surgery | Improved |
| 39 | M | 31 | Lung, skin, muscle, lymph node | MS‐RO− | Surgical muscle biopsy | WT | Chemotherapy | Improved |
| 40 | M | 7 | Skull, radius, vertebrae, pituitary | MS‐RO− | Surgical bone biopsy | WT | Surgery, chemotherapy | Improved |
| 41 | M | 39 | Skull, vertebrae, lung | MS‐RO− | Surgical bone biopsy | WT | Chemotherapy | Improved |
| 42 | F | 32 | Skin, lymph node, liver | MS‐RO+ | Lymph node biopsy | WT | Chemotherapy | Improved |
| 43 | M | 14 | Lung, pituitary | MS‐RO− | Surgical pituitary biopsy | WT | Chemotherapy | Improved |
| 44 | F | 23 | Skull | MS‐RO− | Surgical bone biopsy | V600E | Surgery | Cured |
| 45 | F | 52 | Rib | MS‐RO− | Surgical bone biopsy | V600E | Surgery | Cured |
| 46 | M | 38 | Lung, skin, pituitary, thyroid | MS‐RO− | Thyroid fine needle biopsy | WT | Chemotherapy | Relapse |
| 47 | M | 28 | Lung, alveolar bone | MS‐RO− | VATS lung biopsy, bone biopsy | WT | — | Died |
| 48 | F | 12 | Lung, pituitary | MS‐RO− | Surgical pituitary biopsy | WT | Chemotherapy | Improved |
| 49 | M | 42 | Lung | SS | VATS lung biopsy | WT | Quit smoking | Cured |
| 50 | F | 32 | Lung, pituitary | MS‐RO− | VATS lung biopsy | WT | — | Stable |
| 51 | F | 25 | Skull, vertebrae, skin | MS‐RO− | Skin biopsy | WT | Chemotherapy | Improved |
| 52 | M | 16 | Lung, pituitary | MS‐RO− | Transbronchial lung biopsy | V600E | Chemotherapy | Improved |
| 53 | M | 23 | Lung, skull, pituitary, thyroid | MS‐RO− | Thyroid fine needle biopsy | WT | Chemotherapy | Improved |
| 54 | M | 54 | Vertebrae, pituitary | MS‐RO− | Surgical bone biopsy | WT | Chemotherapy | Improved |
| 55 | F | 47 | Lung, femur, pituitary, thyroid | MS‐RO− | Surgical thyroid resection | V600E | Surgery, chemotherapy | Improved |
| 56 | M | 31 | Lung, skull, pituitary, skin | MS‐RO− | Skin biopsy | V600E | Chemotherapy | Improved |
| 57 | F | 31 | Femur, skull, vertebrae, rib, oral mucosa, pituitary | MS‐RO− | Oral mucosa biopsy | V600E | Chemotherapy | Improved |
| 58 | M | 25 | Pituitary | SS | Surgical pituitary biopsy | WT | Surgery, radiotherapy | Improved |
| 59 | F | 24 | Lung, thyroid, pituitary | MS‐RO− | Thyroid fine needle biopsy | WT | Chemotherapy | Improved |
| 60 | M | 57 | Lung, liver, lymph nodes | MS‐RO+ | Surgical lymph node biopsy | WT | Chemotherapy | Improved |
| 61 | M | 24 | Skull, vertebrae, pituitary | MS‐RO− | Surgical bone biopsy | WT | Chemotherapy | Improved |
| 62 | M | 27 | Lung, pituitary | MS‐RO− | VATS lung biopsy | WT | Chemotherapy | Improved |
| 63 | M | 47 | Lung | SS | VATS lung biopsy | WT | Quit smoking | Cured |
| 64 | M | 47 | Skull | SS | Surgical bone biopsy | V600E | Chemotherapy | Improved |
| 65 | M | 29 | Skull, pituitary | MS‐RO− | Surgical bone biopsy | WT | Chemotherapy | Improved |
| 66 | M | 35 | Lung | SS | VATS lung biopsy | WT | Quit smoking | Improved |
| 67 | F | 48 | Lung, pituitary | MS‐RO− | Surgical pituitary biopsy | WT | Chemotherapy | Improved |
F, female; M, male; MS, multisystem; RO, risk organ; SS, single system; VATS, video‐assisted thoracic surgery; WT, wild type.