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. 2019 Oct 2;9:14197. doi: 10.1038/s41598-019-50732-w

Figure 3.

Figure 3

Inhibiting CDC7 by TAK-931 suppressed cell growth of A375 cells. (A,B) A375-P & WM983B-P and resistant A375-R & WM983B-R cells were treated for 5 days with different concentrations of TAK-931 and the cytotoxicity was assessed by cell counting kit-8 assay. (C) Western blot analysis was performed to compare the expression of CDC7 and the activity of p-MCM2 and p-ERK in A375-R cells after treatment of these cells with 2.5 µM of Vemurafenib and 500 and 1000 nM of TAK-931 for 48 hours. *, @Depicts significance at p < 0.05 relative to untreated parental (P) and resistant (R) cells, respectively.