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. 2019 Oct 2;9:14197. doi: 10.1038/s41598-019-50732-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Suggested treatment strategy in Vemurafenib-resistant melanoma patients with CDC7 inhibitor, TAK-931. Diagrammatic representation of the suggested strategy for treatment of melanoma patients with CDC7 inhibitor who had BRAF mutation and developed resistance against Vemurafenib. If CDC7 expression is high in the tissues of these patients, they are expecting to receive CDC7 specific inhibitor TAK-931 sequentially to Vemurafenib treatment and after developing signs of drug resistance. Another strategy is to increase the bioavailability of miR-3613-3p to the tumor cells, where it targets CDC7 and its downstream signaling. This intervention is anticipated to reduce the drug resistance and improve the clinical outcomes of the melanoma patients.