Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Oct 2;9:14171. doi: 10.1038/s41598-019-48898-4

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Culturable enumeration at BCP conditions (2 hours at five times MIC) demonstrating antimicrobial activity of compounds by a second method. All compounds exhibit >2 log-fold reduction in culturable units, providing supporting evidence for observed BCP phenotypes to be indicative of significant antimicrobial action. DPA 154 and 156 significantly decrease viable cell count at 2 hours similar to polymyxin-B. DPA 154/A22 combination reduced culturable cell count greater than either DPA 154 or A22 alone, supporting synergistic interaction demonstrated in synergy studies. Hoechst dyes induced less reduction in viable cells at 2 hours than DPA 154/156 test compounds. NT (No treatment), Cipro (Ciprofloxacin), H (Hoechst dye control), PB (Polymyxin-B), A22 (S-(3,4-dichlorobenzyl)isothiourea. Mid exponential phase cultures of E. coli were used for antibiotic challenge. Error bars represent two individual experiment repeats with two duplicates.