Table 3.
Univariate and multivariate Cox proportional hazard models to define the independent impact of on cardiac events.
| Variable | univariable analysis | multivariable analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | |
| Age | 1.011 | 0.983–1.039 | 0.447 | |||
| Sex | 1.371 | 0.506–3.715 | 0.535 | |||
| History of syncope | 6.496 | 2.493–16.924 | <0.001 | 4.99 | 1.881–13.237 | 0.001 |
| ICD | 6.748 | 2.469–18.443 | <0.001 | |||
| NYHA III - IV | 0.455 | 0.175–1.188 | 0.108 | |||
| LV involvement on CMR | 5.49 | 1.255–24.022 | 0.024 | |||
| Presence of LGE | 3.577 | 1.027–12.458 | 0.045 | |||
| Fat infiltration | 1.068 | 0.306–3.731 | 0.918 | |||
| LVEDVi | 1.009 | 0.996–1.022 | 0.178 | |||
| LVESVi | 1.01 | 0.992–1.029 | 0.289 | |||
| LVEF <50% | 2.806 | 1.052–7.487 | 0.039 | |||
| RVEF <40% | 0.971 | 0.337–2.797 | 0.957 | |||
| LV GLS >−12.65% | 4.798 | 1.560–14.755 | <0.001 | 3.578 | 1.139–11.245 | 0.029 |
| LV GCS >−13.87% | 4.613 | 1.620–13.140 | 0.002 | |||
| LV GRS <30.27% | 2.838 | 0.997–8.081 | 0.017 | |||
Abbreviations: ICD: implantable cardioverter-defibrillator, NYHA: New York Heart Association, LV: left ventricular, CMR: cardiac magnetic resonance, LGE: late gadolinium enhancement, LVEVDi: LV end-diastolic volume index, LVESVi: LV end-systolic volume index, LVSV: LV stroke volume, LVEF: left ventricular ejection fraction, RVEF: right ventricular ejection fraction, GLS: global longitudinal strain, GCS: global circumferential strain, GRS: global radial strain.